Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11
نویسندگان
چکیده
An enduring problem in biology is explaining how novel functions of genes originated and those diverge between species. Despite detailed studies on the functional evolution a few proteins, molecular mechanisms by which protein have evolved are almost entirely unknown. Here, we show that polyalanine tract homeodomain transcription factor HoxA11 arose stem-lineage mammals as an autonomous repressor module physically interacting with PAH domains SIN3 proteins. These results suggest long tracts, common factors often associated disease, may tend to function can contribute diversification despite deleterious consequences expansion.
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ژورنال
عنوان ژورنال: Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution
سال: 2021
ISSN: ['1552-5015', '1552-5007']
DOI: https://doi.org/10.1002/jez.b.23063